Police in Massachusetts have issued a warning about heroin cut with a synthetic cannabinoid—intended only for research purposes—that may not respond to Narcan.
In the city of Holyoke, first responders say they have observed behavior consistent with PCP use when responding to some heroin overdoses, including “bizarre, self-destructive physical behaviors such as attempting to jump from high places and fleeing into busy traffic patterns.” An analysis of heroin found at one of the scenes determined the heroin was laced with MDMB-4en-PINACA.
MDMB-4en-PINACA butanoic acid metabolite is an analytical reference standard that is structurally similar to known synthetic cannabinoid metabolites. According to Cayman Chemical, the product is intended for research and forensic applications as an analytical reference standard. In fact, it specifically comes with a warning that the product is not for human or veterinary use.
Ambulance crews in Holyoke initially had trouble diagnosing overdoses as violent behavior is typically not a symptom of a heroin overdose. Additionally, Narcan (Naloxone) may have no effect on the patient as the amount of heroin present in the sample can vary from none to a partial amount. First responders are observing respiratory issues, dangerous heart rates and extremely high blood pressures, among other reactions.
In a statement, the Holyoke Police Department noted that many heroin users have a “comfort level” with their substance abuse as they carry Narcan and feel they can manage and survive an overdose.
“This new substance should alter that thinking,” the department said.