A new system developed by researchers from the Forensic Science Service uses an instrument loaded with a DNA processing cartridge to speed the DNA analysis. Using this system, the entire process from taking the sample from a suspect, to database compatible DNA profile production can be achieved in less than 4 hours.

“Our vision for the future is to have a single fully integrated injection-molded cartridge with reagents preloaded with capability for DNA purification, amplification and μCE-based separation. Such a cartridge, coupled with automatic channel finding and focusing will minimize set up time and make the system usable by an individual with very basic training,” the researchers conclude. Their goal is to improve their system so that a profile can be attained in a mere two hours.

“However, the rapid delivery of a DNA profile, whether at a crime scene, or in a custody suite is only a part of the puzzle. If the full impact of these new technologies is to be gained, the rapid delivery of chemistry must be supported by a capability to submit and compare the DNA profile in near real time. Currently neither the CODIS database, nor the UK National DNA database have the capability to support rapid chemistry protocols,” they add.

Source: Analytical Chemistry